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Roundup®: Converging Pattern of Toxicity from Farm to Clinic to Laboratory Studies

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roundup toxic

A Roundup of Roundup® Reveals Converging Pattern of Toxicity from Farm to Clinic to Laboratory Studies

We need to ban glyphosate from our own communities as most governments fail to protect citizens

Institute of Science in Society   1/19/15

**please support research of Seralini’s team on analysing glyphosate residues in rats exposed to Roundup here: http://www.i-sis.org.uk/Support_Seralini_Team_for_New_GMO_Risk_Research.php

Dr Eva Sirinathsinghji

What is glyphosate?

Glyphosate, perhaps surprisingly for a chemical so ubiquitously associated with our food, was not first used as an agricultural chemical but instead first patented as a metal chelator in 1964 by Stauffer Chemical company (US 3160632 A) [1] and used as an industrial pipe cleaner. It was later patented by Monsanto as an herbicidal agent in 1974 (US3799758 A) [2] based on its ability to block the shikimate pathway involved in the production of aromatic amino acids in both plants and bacteria. It has become the most popular herbicide in the world especially since glyphosate tolerant genetically modified (GM) crops were commercialized in the mid-1990s, together with the assumption (perpetrated by Monsanto) that the herbicide is safe for health and the environment. In 2010, it was also patented by Monsanto as an antibiotic agent. Moreover, it is being increasingly used as a pre-harvest desiccant for drying seeds, a process that results in contamination of non-GM grains, one of the main exposure routes in the EU where GM crops are not commonly grown. Thus, an estimated 70 % of UK oil seed rape (canola) and 50-60 % of EU sunflowers are sprayed with glyphosate [3], resulting in products of major food brands in the UK testing positive for glyphosate residues in a 2014 analysis by GM Freeze, with glyphosate the most commonly detected of all chemicals [4].

All of glyphosate’s chemical properties already mentioned have implications for the health of both people and planet. Scientific research has additionally implicated glyphosate as an endocrine disruptor and a DNA mutagen; and it affects over 291 different enzymes in the body [5]. It is increasingly linked with a wide variety of illnesses, the sharp rises in illnesses occurring in parallel with glyphosate application across various GM cultivating regions of the world.

The most convincing evidence of glyphosate toxicity is the consistent pattern of diseases associated with glyphosate that has emerged from the farm to the clinic and from scientific studies to citizen testimonials.

Glyphosate widespread in the environment and in our bodies

Glyphosate’s popularity is due in large measure to its concomitant use with the most widely planted type of GM crops, those tolerant to glyphosate-herbicides. Monsanto commercialised the first Roundup-ready crop in 1996 (Roundup being the commercial formulation containing ‘adjuvants’ that make it much more toxic than the active ingredient glyphosate alone, see later). In countries such as Argentina where large swaths of the country have been dubbed soy deserts, GM soybean cultivation has resulted in an 858 % rise in glyphosate use (see [6] Devastating Impacts of Glyphosate Use with GMO Seeds in Argentina, to appear). Similarly, the US has seen even greater rises of 2 500 % from 1987 to 2007 [7].

This widespread and massive application of glyphosate herbicides has resulted in almost ubiquitous contamination of the environment. A 2014 study on US water systems across 38 states found glyphosate and its principle metabolite AMPA (aminomethylphosphonic acid) not only in rivers, lakes and streams, but also rain, soil and sediment, ditches and drains and groundwater (see [7]). Some 70 % of rain samples tested positive for glyphosate. Similarly in Europe, (in Catalonia, a large region of Spain) it was found that all 11 groundwater sites were positive for glyphosate despite it being a region free from glyphosate-tolerant crop cultivation; 41 % of samples were above detection limits [8]. The detection in groundwater goes against one of the claims on glyphosate safety that its propensity to bind to soil and sediment means it will not leach into our fresh water supplies. In Argentina, new data of rain sample measurements averaged an extreme 6.5 µg/L and reaching as high as 67 µg/L (67 ppt) across four regions from October 2012 to April 2014 [9]. These levels are far higher than those seen in US rain samples where the average and maximum concentrations were 0.11 µg/L and 2.5 µg/L respectively [7]. Read the rest of this entry »

Ban Glyphosate Herbicides Now: Scientists Confirm Potent Hormone Disrupting Effects

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RoundupBy Dr. Mae-Wan Ho   Institute of Science in Society

Latest evidence confirms world’s top-selling herbicide used with GM crops is toxic and disrupts sex hormones at infinitesimal doses; time for a worldwide ban   

Scientific evidence of glyphosate and Roundup toxicities piling up

Glyphosate is the world’s top selling herbicide, and Monsanto’s formulations Roundup is used with more than 80 percent of all genetically modified (GM) crops grown globally. But evidence of its extreme toxicity has been emerging within the past decade. Glyphosate was found to kill human placental cells at concentrations below that recommended for agricultural use and approved by our regulators, while Roundup was lethal at even lower concentrations [1] Glyphosate Toxic & Roundup Worse , SiS 26). The herbicide has already been linked with spontaneous abortions, Hodgkin’s lymphoma and multiple myeloma in humans; and in laboratory studies glyphosate caused liver damage in rats. Roundup is also highly lethal to amphibians [2] ( Roundup Kills Frogs , SiS 26).

Recently, the research team led by Giles-Eric Séralini at Caen University in France confirmed the lethality of glyphosate and Roundup formulations to human cells at minute concentrations (down to parts per million, ppm) [3] ( Death by Multiple Poisoning, Glyphosate and Roundup , SiS 42). They also identified three main targets for killing cells: damage to the cell membrane, poisoning of energy metabolism in the mitochondria, and programmed cell death involving fragmentation of nuclear DNA.

Read the rest of this entry »

Written by laudyms

July 23, 2009 at 11:07 am